Question

explain the correlation between phenobartial and seizures. How does the medication work to control seizures?

Answer 1

phenobarbital is useful in controlling facal aware ,generalixed tonic clonic and focal impared awarness seizures in patients of all age group this medication is considered as first choice to treat certain kind of seizures in child less than one year of age,The mechanism of action of phenobarbital is this drug increases the amount of time chloride channerls are open, which turn depresses the central nervous system, this action occurs by action on GABA. receptor sbunits, this increases the threshold for the action potential,these the reason this drug is effective in the treatment of seizures,As per the clearence and metabolism it is a watersoluble agent metabolized in the liver and expelled through renal system.

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