Question

evaluation of medication effectiveness of MONOBACTAMS

Answer 1

evaluation of medication effectiveness of MONOBACTAMS

Monobactams are monocyclic and bacterially-produced β-lactam antibiotics. The β-lactam ring is not fused to another ring, in contrast to most other β-lactams.Monobactams are effective only against aerobic Gram-negative bacteria (e.g., Neisseria, Pseudomonas).

1,effect against gram negative bacteria

Monobactams are parenteral beta-lactam bactericidal antibiotics.

Aztreonam is currently the only available monobactam. Aztreonam has activity similar to that of ceftazidime against

• Enterobacteriaceae that do not produce AmpC beta-lactamase, extended-spectrum beta-lactamase (ESBL), or Klebsiella pneumoniae carbapenemase (KPC)

• Pseudomonas aeruginosa

2.similar spectrum as aminoglycosides & 3rd generation cephalosporins

3.may be used in patients with a history of penicillin anaphylaxis that have serious infections (e.g. pneumonia, meningitis & sepsis) caused by gram-negative bacteria.

4.penetrates well into the CSF

5.these agents can be administered to patients who have a penicillin allergy.( patients who are allergic to penicillins or cephalosporins (except for ceftazidime) can safely receive aztreonam. Conversely, patients who have reacted to aztreonam can safely receive penicillins and cephalosporins (except for ceftazidime).

6. Aztreonam also is approved by the US Food and Drug Administration (FDA) as an inhalational antibiotic for children with cystic fibrosis who are 7 years or older, for the treatment of P. aeruginosa lower respiratory tract infection.

8. incomplete in coverage and limited spectrum of activity

7. no activity against either Gram-positive organisms or anaerobes.