Question

necessary reasons to apply a correction such as that based on the jukes cantor model when calculating distance values from multiple sequence alignments

Answer 1

Jukes Cantor model

The Jukes-Cantor model is a Markov model of evolution that assumes. that the substitution of a base with any other base occurs with equal prob- ability. The mutation probability, or rate, is given by the factor a with. dimensions of mutations/generation.

Necessary reason to apply :

  Distances writes a matrix of the pairwise evolutionary distances between aligned sequences.There are many methods for the calculation of these distances. Some of them are, Kimura's two-parameter method, the Tajima-Nei method, the Jin-Nei gamma distance method, and the Tamura method. One of the methot that can be used in any of the cases is the Jukes Cantor model. Since it is an unprovinced matrix, there is a chance of obtaining an uncorrected distance.

So in the above case, a correction should be applied for better calculation of the final matrix.