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What does it physically mean if "leaf" and "target" modes show different conformations? Why? GC's are...

What does it physically mean if "leaf" and "target" modes show different conformations? Why?

GC's are the strongest basepairs. Why shouldn't one just make ALL target bonds GC basepairs?

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Answer #1

In the DNA helix,the bases such as adenine, cytosine, thymine and guanine are each linked with their complementary base using hydrogen bonding.

Adenine pairs with thymine using 2 hydrogen bonds. Guanine pairs with cytosine using 3 hydrogen bonds.This makes a difference in strength between the two sets of Watson and Crick bases.

Guanine and cytosine bonded base pairs are more stronger than thymine and adenine bonded base pairs in DNA. This difference in strength is due to the difference in the number of hydrogen bonds.

Due to the complementary base pairing each base can only bond with a specific base partner. therefore all target bonds is not possible with GC pairs

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