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What are the three regulatory enzymes in the tca cycle and what are their effector molecules?

What are the three regulatory enzymes in the tca cycle and what are their effector molecules?

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Answer #1

The citric acid cycle is regulated by three simple mechanisms.

  1. Substrate availability
  2. Product inhibition
  3. Competitive feedback inhibition.

All of the regulatory enzymes of the citric acid cycle are allosterically inhibited by NADH.

ATP is an allosteric inhibitor of pyruvate dehydrogenase and isocitrate dehydrogenase.

Calcium is also used as a regulator of the citric acid cycle.Calcium activates many enzymes such as isocitrate dehydrogenase and pyruvate dehydrogenase complex.

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