Assume that the solubility of caffeine in water is 4.0 g/100 mL and in methylene chloride it is 16.0 g/100 mL at 25°C. What is KD for this system?
KD = Partition coefficient
KD = [Caffeine]H2O / [Caffeine]CH2Cl2
= (4.0 g/100 mL) / (16.0 g/100 mL)
= 4 / 16
The distribution coefficient of caffeine between water and methylene chloride is 0.25
KD = [Caffeine]CH2Cl2 / [Caffeine]H2O
= (16.0 g/100 mL) / (4.0 g/100 mL)
= 16 / 4
The distribution coefficient of caffeine between methylene chloride and water is 4.
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