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we have seen the Mg2+ play an inhibitory role in the uncatalyzed hydrolysis of ATP (phosphoryl...

we have seen the Mg2+ play an inhibitory role in the uncatalyzed hydrolysis of ATP (phosphoryl transfer to water). Please discuss the inhibitory role the magnesium ion can play on phosphoryl transfer.

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Phosphoryl transfer is a fundamental reaction. kinases are enzyme that catalyses the transfer of a phosphoryl group from ATP to an acceptor. hexokinase then catalyzes the transfer of phosphoryl group from ATP to a variety of 6 carbon Sugars such as glucose and mannose. Hexokinase like adenylate kindness and all other kindness is required in Mg2+ for activity. The divalent metal Ion forms a complex with ATP. magnesium ion is required as the reactive form of ATP is related Complex with Mg2+ ion. This step is a direct nucleophilic attack of the hydroxyl Group On The Terminal phosphoryl group of the ATP. This produces glucose 6 phosphates and ADP.

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