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does the present of two aspartic acid residues near the N-terminus of the alpha helix destabilize...

does the present of two aspartic acid residues near the N-terminus of the alpha helix destabilize the alpha helix?

please explain in depth

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Answer #1

We know that aspartic acid have a mean frequency Pk for alpha helix = 0.94 beta sheet = 1.55

therefore

aspartic acid is preffered in the beta conforamation due to its polar side chain ( - COOH group)

yes ,  the presence of two aspartic acid residues near the N-terminus of the alpha helix destabilize the alpha helix because aspartic acid has a polar -COOH side chain which leads to a large deviation in the alpha helix by causing a large steric strain.

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