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During an experiment if the products of a reaction are both of same nature,lets say both are organic compounds and ether soluble and both are water insoluble and if one of is an organic acid,it can be changed to water soluble by reacting with a base.And this acidic organic compound on reacting with base becomes water soluble compound and can be separated or extracted form the mixture.
The solubilities of acidic and basic compounds can thus be changed at will.
Once the layers are separated as before, the neutral acid or base can be regenerated by yet another acid-base reaction
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