3. Xylose has a similar structure as glucose except that it has a hydrogen atom at C-6 instead of the hydroxymethyl (-CH2OH) group.
a. Please look up and draw the structures of glucopyranose and xylopyranose below. For each structure you have drawn, please indicate if it is an alpha- or a beta- anomer.
b. It has been observed through experiment that the rate of ATP hydrolysis by hexokinase is markedly enhanced in the presence of xylose than in the presence of glucose. Suggest a possible explanation for this observation. (Hint: the phosphoryl group acceptor may not necessarily be a monosaccharide)
a)b) Hexokinase is the enzyme that catalyzes this phosphoryl group transfer.Hexokinase undergoes and induced-fit conformational change when it binds to glucose, which ultimately prevents the hydrolysis of ATP. Thatis why rate of ATP hydrolysis by hexokinase is markedly enhanced in the presence of xylose than in the presence of glucose .It is through -CH2OH group of glucose it binds ,it is rather absent in xylose.
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