Question

Enviromental Biochemistry How is phase I metabolism regulated, and how does this relate to “resistance” against...

Enviromental Biochemistry

How is phase I metabolism regulated, and how does this relate to “resistance” against the effects of xenobiotics? How does the Ah receptor fit into this?

Science   Chemistry   
0 0
Add a commentTranscribed image text
Next >

Homework Answers

Answer #1

In phase I metabolism, enzymes introduce reactive and polar groups into their substrates which increses the polarity of molecules. Phase 1 reaction occurs by oxidation, reduction, hydolysis, cyclization, decyclization, addition of oxygen and removal of hydrogen carried out by cyctochrome P-450 dependent mixed function oxidases. This enzyme family catalyse the oxidative biotransformation of most drugs and other lipophilic xenobiotics Ah receptor is aryl hydrocarbon receptor which serves as key mediators of drug induced changes in phase 1 mtabolizing enzymes..

0 0
Know the answer?
Your Answer:

Post as a guest

Your Name:

What's your source?

Earn Coins

Coins can be redeemed for fabulous gifts.

Log In

Sign Up

Not the answer you're looking for?
Ask your own homework help question
Similar Questions
What is pKa and how does it relate to drugs? Question # 4: What is the...
What is pKa and how does it relate to drugs? Question # 4: What is the blood brain barrier and how does it help to protect us from foreign substances? Question # 5: What iis the difference between passive and active diffusion of drugs across the blood brain barrier? Question # 6: What is the difference between Phase I and Phase II biotransformation? Question # 7: What is first pass metabolism and how does it compare to an active metabolite?...
a) How does the equilibrant relate to the resultant? b) If I had 4m pointing east...
a) How does the equilibrant relate to the resultant? b) If I had 4m pointing east and I subtracted 2m pointing west, what would my resultsnt be?
Explain how Zen calls us to live in the present moment. How does this relate to...
Explain how Zen calls us to live in the present moment. How does this relate to the ancient Buddhist idea of anatman? What are the principles of Not-Two and Not-One, especially in the context of the I vs Other distinction?
i want to know what does model fit mean & how to put it?
i want to know what does model fit mean & how to put it?
How do I plot an appropriately labelled graph of ln (T∞ - Tt)against time (t) and...
How do I plot an appropriately labelled graph of ln (T∞ - Tt)against time (t) and calculate the rate constant (k) from the slope (gradient) using a line of best fit? I want the graph drawn by hand. The ln(A)0 are ( 2.31,2.16,2.09,2.37,2.34,2.06,2.09,2.09,2.09) and the time (10,20.5,30,40.1,50.27,60,70,80,90) 10 20.5 30 40.1 50.27 60 70 80 90 2.31 2.16 2.09 2.37 2.34 2.06 2.09 2.09 2.09
QUESTIONS FOR SERIES AND PARALLEL CIRCUITS 1. i) How does the equivalent resistance of a series...
QUESTIONS FOR SERIES AND PARALLEL CIRCUITS 1. i) How does the equivalent resistance of a series circuit compare to each individual resistor? ii) Answer the same question for a parallel circuit? 2. Assume that you have three 2Ω resistors. Show using a schematic drawing, how youwould connect these together to achieve the following resistances: (a) 1Ω, (b) 3Ω, and (c)4 Ω. Note that you do not always have to use all three resistors to achieve your goal. PAGE 2 3....
How does lipid solubility effect hemolysis of red blood cells? I know that lipid solubility of...
How does lipid solubility effect hemolysis of red blood cells? I know that lipid solubility of ethanol is greater than ethylene glycerol and glycerol. However, I don’t understand how that effects hemolysis, since it focuses on concentrations of solutes effect on the diffusion of water in and out of the cell?! Please help lol
1. a. What is “TBTF?” - Too Big to Fail i. Does the “B” relate to...
1. a. What is “TBTF?” - Too Big to Fail i. Does the “B” relate to assets? Deposits? Net cost of a P&A to the FDIC? ii. Does the “F” mean revoking the charter? FDIC receivership? A bridge bank? iii. Discuss the potential ambiguities. b. How would higher capital requirements (CET1, Leverage, capital buffers, etc.) affect the incidence of TBTF actions? 2.         Closed Bank’s balance sheet: Assets ($mm) Liab. & Capital Good Assets 17,000 Insured Dep. 19,900 Questionable Assets...
How do you relate the most to this story and why? In two strong paragraphs, explain...
How do you relate the most to this story and why? In two strong paragraphs, explain what it is about the tone and/or imagery of the story that speaks to you and why. Use some text examples to support your response Hills Like White Elephants (1927) The hills across the valley of the Ebro1 were long and white. On this side there was no shade and no trees and the station was between two lines of rails in the sun....
What are 4 key things you learned about the topic from reading their paper? How does...
What are 4 key things you learned about the topic from reading their paper? How does the topic relate to you and your current or past job? Critique the paper in terms of the organization and quality. Team 3 answer questions above. Part I In today’s world we see fear among people when dealing with sexual harassment. This leads to people not reporting sexual harassment. A misconception about sexual harassment is that it’s only about touching and forcing other people...
ADVERTISEMENT
Need Online Homework Help?

Get Answers For Free
Most questions answered within 1 hours.

Ask a Question
ADVERTISEMENT