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Phosphofructokinase (PFK) and phosphofructokinase 2 (PFK2) catalyze similar reactions. List one thing that is the same...

Phosphofructokinase (PFK) and phosphofructokinase 2 (PFK2) catalyze similar reactions. List one thing that is the same about the reactions and one thing that is different.

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Answer #1

Common point:

PFK and PFK2 are mostly found in liver.

Difference:

Phosphofructokinase (PFK) is the rate limiting enzyme and main control point in glycolysis. In this reaction, fructose -6-phosphate is phosphorylated to fructose 1,6-bisphosphate using ATP.

PFK is inhibited by ATP and citrate and activated by AMP.

If glycolysis is running PFK2 is active when phosphorylated in liver. PFK2 is probably active when it is dephosphorylated.

When PFK2 is phosphorylated by protein kinase A in liver and thus glycolysis is inhibited.

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