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Name four allosteric modulators of glycolysis and/or gluconeogenesis, and for each, state what enzyme(s) they modulate,...

Name four allosteric modulators of glycolysis and/or gluconeogenesis, and for each, state what enzyme(s) they modulate, whether they are activators or inhibitors, and the logic of the nature of the modulator (i.e., why would these molecules be used as allosteric modulators).

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Answer #1

Glycogenesis and gluconeogenesis are the two important processes to maintain the blood glucose levels .

The main allosteric modulators (affector molecules) of glycogenesis and gluconeogenesis are

(i). ATP (high energy charge)

(ii). Citrate

(iii). AMP (low energy charge)

(iv). Fructose-2,6-BP

(v). Fructose-1,6-BP

(vi). glucose-6P

Action of these modulators on different enzymes given below :

Phosphofructokinase-1 (PFK-1)

inhibited by  - & .

activated by - &

Pyruvate kinase

inhibited by -

activated by -

Hexokinase

inhibited by -

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