Question

A variety of factors influence enzyme activity. Substances that bind to the enzyme and interfere with substrate binding or catalysis are inhibitors. Identify the type of inhibition associated with each of the following descriptions and examples by assigning: (a) Irreversible Inhibition (b) Competitive Inhibition (c) Mixed Inhibition

1.            _______Inhibitor may permanently modify an enzyme

2.            _______Tamiflu, a transition state analog, reversibly binds to neuraminindase

3.            _______Inhibitor binds reversibly to an enzyme's active

4.            _______Inhibitor binds to an enzyme at a site other than active site

5.            _______The Al3+ ion binds to acetylcholinesterase or to the acetylcholinesterase- substrate complex

6.            _______DIPF permanently modifies the hydroxyl group of a Ser residue at the active site

Answer 1