Question

1a. How are nucleophilic addition and nucleophilic acyl substitution not similar?

Nu:- reacts at carbonyl carbon

tetrahedral intermediate is formed

both have a good leaving group

1b. Acyl chlorides are ___ reactive than amides because ____.

less

more

same

Cl makes the carbonyl C less electrophilic

Cl makes the carbonyl C more electrophilic

resonance

1c. ROH reacts with RCOOH to form:

acyl chloride

amide

ester

ROH2+

1d. Which reaction will not make a ROH?

ester + LiAlH4

ester + Grignard

ester hydrolysis

ester + NH3

none

1e. The formation of an imine from an aldehyde or ketone is like a nucleophilic acyl substitution reaction (an acyl group has a C=O bond but the imine has a C=N bond). Acetone reacts with methyl amine to form an imine. What is the leaving group in this reaction? Give the chemical formula, not the name, of the leaving group

Answer 1