Question

a. If the values obtained for LogKow of a drug is the same in different extraction...

a. If the values obtained for LogKow of a drug is the same in different extraction volumes, what could account for this similarity and if they are different, what accounts for this variation?

b. Is the equilibrium constant the same for a sample even when different concentrations are used in different experimental runs.

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Answer #1

Ans:The octanol/water partition coefficient (Kow) is defined as the ratio of a chemical's concentration in the octanol phase to its concentration in the aqueous phase of a two-phase octanol/water system.

Kow = Concentration in octanol phase / Concentration in aqueous phase

logKow of a drug is the same in different extraction volumes it means ratio of  concentration in octanol phase / Concentration in aqueous phase is same.

If logKow of a drug is different in different extraction volumes it means ratio of  concentration in octanol phase / Concentration in aqueous phase is different.

Ans: the equilibrium constant is the same for a sample even when different concentrations are used in different experimental runs.

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