Question

10. Given the following DNA sequence as the template strand: TTACGATGCCCA Finish the complementary DNA strand. AAT _ _ _ _ _ _ _ _ _ Finish the corresponding mRNA (use template strand) AAU _ _ _ _ _ _ _ _ _ Finish the corresponding protein sequence from the mRNA. (Use the table on mRNA codons to identify the protein sequence. For example, the mRNA codon AAU codes for the amino acid, asparagine, Asn. Asn-____-____-____ What would be the effect on the protein (amino acid) sequence if the first A in the DNA sequence was mutated to a G? What would be the effect on the protein (amino acid) sequence if the first T in the DNA sequence was mutated to an C? What could happen if the wrong amino acid is incorporated into a protein?

Answer 1

Ans 10 :

The complimentary strand for the DNA template strand will be given as :

AATGCTACGGGT

The corresponding mRNA strand will be given as :

AAUGCUACGGGU

The protein sequence will be given as :

Asn-Ala-Thr-Gly-

If the first A in the DNA sequence is mutated to G , then the first mRNA codon will AAC , so the protein sequence will be :

Asn-Ala-Thr-Gly-

So basically no change in the protein sequence

If the first T is mutated to C , then the first mRNA codon will be GAU , so the protein sequence will be :

Asp-Ala-Thr-Gly-

If wrong amino acids are incorporated in the protein molecule , it can lead to mutations in the body. The protein molecule may not perform the functions it is destined to. It may lead to several anomalies in the body system.