Kinetic constants for inhibition studies on enzymes are described below. For each part a-h, determine if the numerical values for the constants are identical or different (increased or decreased).
a) Km values in the absence and presence of a competitive
inhibitor
b) Vmax values in the absence and presence of a competitive
inhibitor
c) Km values in the absence and presence of a noncompetitive
inhibitor
d) Vmax values in the absence and presence of a noncompetitive
inhibitor
e) Km values in the absence and presence of an uncompetitive
inhibitor
f) Vmax values in the absence and presence of an uncompetitive
inhibitor
g) Slope in the presence of noncompetitive inhibitor in a
Lineweaver-Burk plot
h) How the y-intercept would will be affected by the presence of
noncompetitive inhibitor
a)
Km value is increased in presence of competitive inhibitor
b)
Vmax value is identical
c)
km value is uneffected
d)
vmax value is decreased in presence of noncompetitive
inhibitor
e)
Km value is decreased in presence of uncompetitive inhibitor
f)
Vmax value is decreased in presence of uncompetitive
inhibitor
g)
slope increases
h)
y intercept increases
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