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A 70 kg subject received 10 mg of diazepam. The plasma concentration, extrapolated to time zero...

A 70 kg subject received 10 mg of diazepam. The plasma concentration, extrapolated to time zero was 120 ng/ml. Calculate the (f)Vd in liters/kg.

Please make sure Vd is in L/kg!!

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Answer #1

Solution.

The volume of distribution,Vd represents a hypothetical volume which relates the amount of drug in the body to the plasma concentration by the equation

where Abis the amount of drug in the body which also equals the amount of administered drug, and C is the concentration of drug in the plasma.

As a 10 mg dose (or 107 ng) is administered, and the plasma concentration, extrapolated to time zero is 120 ng/ml, the volume of distribution is

As the mass is 70 kg, it is 83.3/70 = 1.19 L/kg.

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