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The addition of H- and NAD+ os highly reversible to a reaction. Explain why in a...

The addition of H- and NAD+ os highly reversible to a reaction. Explain why in a brief paragraph why NAD+ is such a good hydride (H-) acceptor and why NADH is a good hydride donor? (Hint: Think of structural features)

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Answer #1

The reason can be explained by looking at the structure of both NAD+ and NADH. In case of NAD+, the positive charge on N atom of pyiridine ring of nicotinamide drives it to accept hydride and get rid of positive charge. But at the same time, it loses its aromaticity. Whereas in case of NADH, although N atom does not have positive charge but it has also lost aromaticity so again it wants to go back to aromatic form by donating hydride. So overall this change lies in equilbrium.

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