Based on chromatographic theory (how a TLC plate works) which of the four known analgesics is the most polar and which is the least polar? Explain reasoning.
Acetominiphen, Aspirin, Caffeine, Naproxen.
From:
Acetominiphen, Aspirin, Caffeine, Naproxen
Caffeine>Acetaminophen> Naproxen > Aspirin
Caffeine
the most polar since it has 4 nitrogen atoms (rich in electrons)
Thee amide bonding (C=O NH2) makes it even more polar.
Acetaminophen
the phenic group is polar,
It also has 1 amide
Naproxen
it has no amides but has two acidic groups COOH... those are pretty polars
Aspirin
has only a COOH group (carobxilic acid) therefore, it is the least polar, yet polar!
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