Question

The free energy of hydrolysis of a peptide bond is typically exergonic but the peptide bond...

The free energy of hydrolysis of a peptide bond is typically exergonic but the peptide bond is stable for many years. Why?

Homework Answers

Answer #1

In Thermoodynamics, if the energy of products is lower than reactants then the reaction is exergonic and it indicates the reaction is feasible

but in terms of kinetics, the speed of a reaction depends on the energy barrier of the reaction between reactants and products and that energy is called activation energy

If activation energy of the reaction is low, the reaction occcurs fastly

If activation energy of the reaction is high, the reaction occcurs slowly

For the hydrolysis of peptide bond although free energy is -ve it occurs slowly because the activation energy is very high

Know the answer?
Your Answer:

Post as a guest

Your Name:

What's your source?

Earn Coins

Coins can be redeemed for fabulous gifts.

Not the answer you're looking for?
Ask your own homework help question
Similar Questions
Matters of stability. Proteins are quite stable. The lifetime of a peptide bond in aqueous solution...
Matters of stability. Proteins are quite stable. The lifetime of a peptide bond in aqueous solution is nearly 1000 years. However, the free energy of hydrolysis of proteins is negative and quite large. How can you account for the stability of the peptide bond in light of the fact that hydrolysis releases considerable energy?
Referring to peptide bond formation in amino acids, the equilibrium lies on the side of hydrolysis,...
Referring to peptide bond formation in amino acids, the equilibrium lies on the side of hydrolysis, but peptide bonds and kinetically stable. Explain this ( I don't get what they mean by this)
Is the HYDROLYSIS of ATP endergonic or exergonic? Is the CONDENSATION of ATP endergonic or exergonic?...
Is the HYDROLYSIS of ATP endergonic or exergonic? Is the CONDENSATION of ATP endergonic or exergonic? WHY? HOW?
Relate the structure and function of the ATP molecule with the following terms: endergonic/exergonic: stable/unstable: free...
Relate the structure and function of the ATP molecule with the following terms: endergonic/exergonic: stable/unstable: free energy/potential energy: phosphorylation/dephosphorylation:
Which type of reaction forms a peptide bond? Condensation reaction Hydrolysis reaction Cleavage reaction Polymer reaction
Which type of reaction forms a peptide bond? Condensation reaction Hydrolysis reaction Cleavage reaction Polymer reaction
Subject: Cell Biology Why do some books state that the standard free energy for the hydrolysis...
Subject: Cell Biology Why do some books state that the standard free energy for the hydrolysis of the gamma-phosphate group (the one furthest from the ribose) of ATP is different from the standard free energy change for the hydrolysis of the beta phosphate group (the middle phosphate group)? (my textbook shows the same standard free energy change for the hydrolysis of these two groups and that the textbook uses kcal/mol as the unit for free energy (some textbooks use kJ/mol)).
Given the following concentrations typically found in a resting muscle cell, what is the free energy...
Given the following concentrations typically found in a resting muscle cell, what is the free energy change from hydrolysis of ATP to ADP at 25 °C?      ATP = 4 mM      ADP = 9 uM      Pi = 4 mM
The standard free energy change for ATP hydrolysis is -30.5 kJ/mol. Therefore, the free energy change...
The standard free energy change for ATP hydrolysis is -30.5 kJ/mol. Therefore, the free energy change for this reaction in a cell in which the concentration of ATP, ADP, and Pi are 3.1 mM, 2.2 mM and 6.8 mM, respectively, and assuming a physiologically relevant temperature (37 °C), is: Answer -44.25 kJ/mol explain
Explain two reasons why ATP hydrolysis releases a high amount of free energy relative to other...
Explain two reasons why ATP hydrolysis releases a high amount of free energy relative to other biochemical reactions in a cell as it pertains to its phosphate group.  
If bond forming releases energy and bond breaking requires energy, then why is condensation reaction unfavorable...
If bond forming releases energy and bond breaking requires energy, then why is condensation reaction unfavorable and why is hydrolysis favorable?