Question

1.) Which proton comes off first for amino acid titration with base? Which comes off second,...

1.) Which proton comes off first for amino acid titration with base? Which comes off second, third, etc?

2. Compare the different pKa’s with each amino acid.

Homework Answers

Answer #1

1)

2) PKa values of Common Amino Acids

Acid Alpha-carboxy +Alpha Amino R-group
Glycine 2.34 9.60
Alanine 2.34 9.69
Valine 2.32 9.62
Leucine 2.36 9.60
Isoleucine 2.36 9.68
Methionine 2.28 9.21
Phenylalanine 1.83 9.13
Triptophan 2.38 9.39
Proline 1.99 10.60
Serine 2.21 9.15
Threonine 2.63 9.10
Cysteine 1.71 10.78 8.33
Tyrosine 2.2 9.11 10.07
Asparagine 2.02 8.84
Glutamine 2.17 9.13
Aspartic acid 2.09 9.82 3.86
Glutamic acid 2.19 9.67 4.25
Lysine 2.18 8.95 10.79
Arginine 2.17 9.04 12.48
Histidine 1.82 9.17 6.04
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