1.) Which proton comes off first for amino acid titration with base? Which comes off second, third, etc?
2. Compare the different pKa’s with each amino acid.
1)
2) PKa values of Common Amino Acids
Acid | Alpha-carboxy | +Alpha Amino | R-group |
Glycine | 2.34 | 9.60 | |
Alanine | 2.34 | 9.69 | |
Valine | 2.32 | 9.62 | |
Leucine | 2.36 | 9.60 | |
Isoleucine | 2.36 | 9.68 | |
Methionine | 2.28 | 9.21 | |
Phenylalanine | 1.83 | 9.13 | |
Triptophan | 2.38 | 9.39 | |
Proline | 1.99 | 10.60 | |
Serine | 2.21 | 9.15 | |
Threonine | 2.63 | 9.10 | |
Cysteine | 1.71 | 10.78 | 8.33 |
Tyrosine | 2.2 | 9.11 | 10.07 |
Asparagine | 2.02 | 8.84 | |
Glutamine | 2.17 | 9.13 | |
Aspartic acid | 2.09 | 9.82 | 3.86 |
Glutamic acid | 2.19 | 9.67 | 4.25 |
Lysine | 2.18 | 8.95 | 10.79 |
Arginine | 2.17 | 9.04 | 12.48 |
Histidine | 1.82 | 9.17 | 6.04 |
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