Question

The pKa of aspartate is higher in a hydrophobic environment than in an aqueous environment; however,...

The pKa of aspartate is higher in a hydrophobic environment than in an aqueous environment; however, the opposite is true of lysine. Briefly explain why each pKa moves in the direction it does when moving from aqueous to hydrophobic environments. (4 pts)

Science   Chemistry   
0 0
Add a commentTranscribed image text
Next >

Homework Answers

Answer #1

Note that:

aspartate --> Aspartic acid pKa1 = 1.88 pKA2 = 9.60 pKa3 = 3.65 pI = 2.77

lysine --> lysine --> pKa1 = 2.18 pKA2= 8.95 pKA3 = 10.53 pI = 9.74

Note that aspartate is much more acidic in groups. Also, side chain has an acidic COOH group (1 amino group + 2 acidic groups) the pI will be very low for this, meaning htat this is much more acidic overall.

Lysine has a very basic amine group in the side chain, therefore 2 amino group s+ 1 acidic group. pI is pretty higher

0 0
Know the answer?
Your Answer:

Post as a guest

Your Name:

What's your source?

Earn Coins

Coins can be redeemed for fabulous gifts.

Log In

Sign Up

Not the answer you're looking for?
Ask your own homework help question
Similar Questions
Explain why gelatin, which is mostly collagen, is nutritionally inferior to other types of proteins. Globular...
Explain why gelatin, which is mostly collagen, is nutritionally inferior to other types of proteins. Globular proteins are typically constructed from several layers of secondary structure, with a hydrophobic core and a hydrophylic surface. Is this true for a fibrous protein such as B-keratin? Briefly explain your answers for the following questions. a) Is Trp or Gln more likely to be on a protein’s surface? b) Is Ser or Val less likely to be in a protein’s interior? c) Is...
Halophilic bacteria have been developed to live in a very salty environment, e.g. Dead Sea. The...
Halophilic bacteria have been developed to live in a very salty environment, e.g. Dead Sea. The most important salts in the Dead Sea are MgCl2 (1.83 M), NaCl (1.78 M), CaCl2 (0.44 M) and KCl (0.20 M). Typical for halophilic organisms is that their proteins have a much larger (negative) net charge than proteins in organisms that live at normal salinity. (a) Explain why the proteins of halophilic organisms need a large net charge in order for the proteins not...
For The Synthesis of Lidocane answer the following: 1.Why does α-chloro-2,6-dimethylacetanilide only precipitate after an aqueous...
For The Synthesis of Lidocane answer the following: 1.Why does α-chloro-2,6-dimethylacetanilide only precipitate after an aqueous solution of sodium acetate is added? 2.Chloroacetyl chloride is a lachrymator (induces tearing). Give the chemical reaction that occurs on the surface of an eye exposed to this lachrymator. What is the actual agent that produces the irritation and causes the eye to form tears? 3.What happens to the diethylamine that is not extracted from the organic layer when HCl is added and than...
Analyze and answer the following questions: 1- The magnetic force on a charged particle is perpendicular...
Analyze and answer the following questions: 1- The magnetic force on a charged particle is perpendicular to the speed ?⃗ it moves with, so it is said that, in this case, the magnetic force does no work over the charged particle. Explain this statement. 2- Does a magnetic force acting on the moving part of a circuit do work? Justify your statement with an example and the respective equations 3- Build an example, with feasible data, of the magnetic force...
1. All other things being equal, the interest on secured debt is higher than that on...
1. All other things being equal, the interest on secured debt is higher than that on unsecured debt? TRUE OR FALSE 2. the periodic adjustment to the carrying value of longterm debt after each interest payment date is a function of? a. the face rate b. the market rate c. both the face rate and the market rate d. neither the face rate nor the market rate 3.A noninterest-bearing note is always issued at: a. its face value b. a...
1. Triple the net force on an object is : mass triples. acceleration triples. velocity triples....
1. Triple the net force on an object is : mass triples. acceleration triples. velocity triples. 2. As you walk along a level floor, the friction force acting on your feet points in what direction? In the direction of your motion Down Up Cannot decide from the given information Opposite to the direction of your motion speed triples. momentum triples. 3. Let m be your mass. When you are standing up, the normal force acting on you from the floor...
1. Inflammation is generally a protective response, which would normally be beneficial. Is it an exclusively...
1. Inflammation is generally a protective response, which would normally be beneficial. Is it an exclusively beneficial response? Explain 2 pts 2. You are a physician and your patient has had a heart attack resulting in decreased blood flow to the heart tissue. Once blood flow is reestablished, what might be a major concern? 2pts 3. One of the first steps in inflammation is the development of increased adhesiveness of neutrophils to the endothelium cells of venules. How does this...
1. Usain Bolt sprints along the track, with his feet pushing down and behind him. Therefore...
1. Usain Bolt sprints along the track, with his feet pushing down and behind him. Therefore the track actually pushes Usain Bolt along the track. Group of answer choices True or False 2.You study two objects in motion, Object J and Object S. Each object has its own velocity graph, with same time and velocity scales. The slope of each graph is positive, upward and to the right  ⁄ but Object J's tilt angle is only 10º and Object S's tilt...
Task 1: Infant Mortality Rates The U.S. has higher infant mortality rates than other developed nations....
Task 1: Infant Mortality Rates The U.S. has higher infant mortality rates than other developed nations. In the course project, you will examine many aspects of this issue. Begin your investigation of infant mortality rates in the U.S. by gathering and analyzing statistical data. Gather data about infant mortality rates in various countries. Identify five countries that have the lowest infant mortality rates and five countries that have the highest infant mortality rates.Find out the infant mortality rate in the U.S. and evaluate how...
1. Tom Hanks starred in a movie called Castaway. At the beginning, he lives near the...
1. Tom Hanks starred in a movie called Castaway. At the beginning, he lives near the beach, hoping to be rescued, but it means he currently has to carry drinking water from a stream a half-mile away. As hopes of being rescued fade, he decides to move closer to the stream, so he will not have to carry the water supply so far each day. Analyze the effect of moving closer to a water supply on the allocation of time...
ADVERTISEMENT
Need Online Homework Help?

Get Answers For Free
Most questions answered within 1 hours.

Ask a Question
ADVERTISEMENT