A compound is known to have a free amino group with a pKa of 8.8, and one other ionizable group with a
pKa between 5 and 7. To 100 mL of a 0.2 M solution of this compound at pH 9.2 was added 40 mL of a solution
of 0.2 M hydrochloric acid. The pH changed to 6.2. Calculate the pKa of the second ionizable group.
the total dissociation of the compound can be represented by :
H2A <======> H+ + HA-
HA- <=======> H+ + A2-
Where the total compound concentration is represented by [H2A]+ [HA-] + [A2-]
100*0.2/1000=0.02 mol total compund
pH=8.2
HA- + A2- =0.02 mol
8.2=8.8+log(A2-/HA-)
Solving for HA- and A2-, we get
[HA]=0.016 mol
[A2-]=0.004 mol
Adding 40 ml of 0.2 M HCl
40*0.2/1000=0.008 mol H+
Since [A2-] is less than [H+], we dont have to add 0.008
pH=pKa + log ([A-]/[HA])
6.2=pKa+log(0.016/0.004)
6.2=pKa+log(4)
So, pKa=5.6
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