Question

Consider the amino acid histidine, whose side chain pKa = 6.0. Explain what would happen to...

Consider the amino acid histidine, whose side chain pKa = 6.0. Explain what would happen to the histidine pKa if inside of a protein a positively charged lysine was brought into close proximity of the histidine. Do you think the Histidine pKa would increase, decrease, or remain the same? Explain WHY you chose your answer.

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Answer #1

In General Histidine and lysine are basic amino acids. At pKa, 6, the Histidine have positive charge . If the base is added to that histidine, the pH (or pKa) will increases (because base removes hydrogen from its structue and leads to increase in pH or pKa).

Howerver, tthe pKa value of positively chrged lysine is 10.53 (indicates more basic nature compred to that of Histidine). When it was brought into close proximity of the histidine, the pKa value of of histidine insreases.

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