RNA polymerase requires which of the following for initiation? A. DNA primer B. RNA primer C. Supercoiled DNA D. Nicked DNA E. None of the above
Unlike the prokaryotic RNA polymerase that can bind to a DNA template on its own, eukaryotes require several other proteins, called transcription factors.
Primer - strand of short nucleic acid
sequences, generally about 10 base pairs that serves as a starting
point for DNA synthesis.
Supercoiled DNA - compact packing of circular DNA
Nicked DNA - discontinuity in a double stranded DNA molecule
Hence E option is correct. RNA polymerase does require any of these things for initiation.
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