How can amino acid side chains take place in acid base catalysis?
Because polar amino acids have amino and carboxylic acid groups as side chains, these will contribute in acid base catalysis. Examples for such amino acids are serine (Ser), threonine (Thr), cysteine (Cys), asparagine (Asn), glutamine (Gln), and tyrosine (Tyr). Proton transfer is the commonest reaction that enzymes perform. Such reactions are typically acid or base catalysed.
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