Question

Which of the following factors contribute to the large negative ΔG° for the hydrolysis of mixed anhydrides of phosphoric and carboxylic acids such as acetyl phosphate and 1,3-bisphosphoglycerate:

A. Destabilization of the reactant due to bond strain caused by electrostatic repulsion
B. Stabilization of the products by ionization
C. Competing resonances in the reactant relieved by resonance stabilization of the products
D. Entropy effects arising from hydrolysis and ionization

Choose the correct answer:

		all of the above
		all except A
		all except B Incorrect option
		all except C
		all except D

Answer 1

According to my knowledge, the correct answer is Option A (all of the above) since all these options are correct for the hydrolysis of mixed anhydrides

Since all the below statements are correct

A. Destabilization of the reactant due to bond strain caused by electrostatic repulsion
B. Stabilization of the products by ionization
C. Competing resonances in the reactant relieved by resonance stabilization of the products
D. Entropy effects arising from hydrolysis and ionization