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Increased thrombospondin will do which of the following? a. Increase the amount of angiogenesis occurring b....

Increased thrombospondin will do which of the following?

a. Increase the amount of angiogenesis occurring

b. Decrease the amount of angiogenesis occurring.

Science   Chemistry   
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Answer #1

Ans: (b)

Thrombospondins (TSPs) -1 and -2 were among the first protein inhibitors of angiogenesis to be identified, a property that was subsequently attributed to the interactions of sequences in their type I repeats with endothelial cell-surface receptors. The interactions of TSPs-1 and -2 with cell-surface receptors, proteases, growth factors, and other bioactive molecules, coupled with the absence of direct structural functions that can be attributed to these matrix proteins, qualify them for inclusion in the category of 'matricellular proteins'. The phenotypes of TSP-1, TSP-2, and double TSP-1/2-null mice confirm the roles that these proteins play in the regulation of angiogenesis, and provide clues to some of the other important functions of these multi-domain proteins.

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