Question

in the lungs, prostaglandin e2 is an agonist of the receptor of ep2. Determine the receptor then in words, outline the hormonal pathway triggered by pge2

Answer 1

Prostaglandin E₂ receptor 2 (53kDa), also known as EP₂, is a prostaglandin receptor for prostaglandin E₂ (PGE₂). It is encoded by the human gene PTGER2.

The receptor is a G-protein coupled receptor, which activates the G protein Gs.

Like other prostaglandins, dinoprostone can be used as an abortifacient. It is a directvasodilator, relaxing smooth muscles, and it inhibits the release of noradrenaline fromsympathetic nerve terminals. It does not inhibit platelet aggregation, where PGI2 does.

It works by binding and activating the prostaglandin E2 receptor.

It was discovered by Bunting, Gryglewski, Moncada and Vane in 1976.

Up-regulation of PGE2 has been implicated as a possible etiology of nail clubbing.

It is also implicated in duct-dependent congenital heart diseases and is used in infusion in order to open the duct although PGE1 is more commonly used.