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Suppose the glycolytic enzyme, GAPDH, were able to bind ADP and convert GAP all the way...

Suppose the glycolytic enzyme, GAPDH, were able to bind ADP and convert GAP all the way to 3PG, instead of 1,3-BPG. How would this affect the equilibrium for the reaction ?

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Normally, GADPH binds to GAP and converts it to 1.3-BPG which then is converted to 3PG by PGK.

This reaction, GAPà1,3-BPGà3PG is catalyzed by two enzymes which has different parts to play in glycolysis.

Conversion of GAP is regulated by concentration of GAP and NAD+ and this reaction is pulled by next exergonic reaction i.e. 1,3-BPGà3PG.

If the proposed pathway should happen, all the GAP would be directly converted to 3PG without even giving chance to slightly control the pathway. GAP inhibits previous aldolase reaction and that would be lost by proposed pathway.

In gluconeogenic pathway PGK catalyzes the reverse reaction, it would be catalyzed by GADPH only.

If the proposed mechanism is to be true, it would have been non-reversible reaction and equilibrium would be on 3PG side. The concentration of 3PG would have been higher.

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