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Why are some molecules more soluble in the aqueous layer and some in the organic layer?...

Why are some molecules more soluble in the aqueous layer and some in the organic layer?
How do you decide which compounds are more soluble in water?
Science   Chemistry   
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Answer #1

we have a principal for solubility

Like dissolve like.   

it means polar compound dissolve in polar solvents only , non-polar compounds dissolve in non polar solvents only.

suppose take NaCl   which is polar   it dissolve in polar solvent   only like water.

take kirosine will not mix with water can mix with benzene , because both are non-polar.

more the polarity of compound more will be the solubility in water.

one more fact is that if compound is able to form hydrogen bonding it also can dissolve in water.

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