Question

Consider two proteins A and B that interact via two hydrogen bonds that contribute -2 kcal/mol each and two electrostatic bonds that contribute -3 kcal/mol each to the binding energy.

What is the dissociation constant for this interaction? (Note, in this case the reaction is ABßàA + B and the Keq takes all three species A, B and AB into account. Note also that Keq is normalized to standard conditions where all species are at 1M, and therefore Keq is unitless).

Answer 1