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For any enzyme that follows simple Michaelis-Menten kinetics, when the initial velocity of the reaction is...

For any enzyme that follows simple Michaelis-Menten kinetics, when the initial velocity of the reaction is 1/5 of Vmax what is the Substrate concentration?

A) KM << [S]

B) KM = 1/5[S]

C) KM = 4[S]

D) KM = 5[S]

E) KM = [S]

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Answer #1

Correct option:     A) KM << [S]

V0 = Vmax ([S]/([S] + KM))

if initial concentration V0 = Vmax /5 then

KM = -1.25[S]

This represents KM << [S], this can be also obtained from Lineweaver-Burke plot.

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