The induced-fit model is actually an offshoot of an earlier theory proposed by Emil Fischer in 1894, the lock and key model. The lock and key model states that the substrate acts as a 'key' to the 'lock' of the active site. The active site and substrate are exact matches for each other, similar to puzzle pieces fitting together. In this model, only a single substrate is the precise match for the enzyme. Once the enzyme finds its exact counterpart, the chemical reaction can begin.
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