Question

Does Hoffman's Rule apply to E1 Rxns too or to just E2 rxns

Does Hoffman's Rule apply to E1 Rxns too or to just E2 rxns

Science   Chemistry   
0 0
Add a commentTranscribed image text
Next >

Homework Answers

Answer #1

Hoffman rule: According to this rule, beta hydrogen is abstracted by base from the most unhindered (i.e. least substituted) position and least substituted alkene is obtained as a product.

Hoffman rule mostly applies to E2 reactions as in E2 mechanism, a strong and bulky base is used to abstract the beta hydrogen as the mechanism is concerted one. But due to the steric hindrance , bulky base abstracts the hydrogen from the outer surface and give least substituted alkene as product.

e.g.

while E1 elimination takes place through the carbocation intermediate and in this mechanism weak base can also do deprotonation to give alkene.

0 0
Know the answer?
Your Answer:

Post as a guest

Your Name:

What's your source?

Earn Coins

Coins can be redeemed for fabulous gifts.

Log In

Sign Up

Not the answer you're looking for?
Ask your own homework help question
Similar Questions
Please differentiate SN1, E1, SN2, E2.
Please differentiate SN1, E1, SN2, E2.
In this question, as usual, e1, e2, e3 are the standard basis vectors for R 3...
In this question, as usual, e1, e2, e3 are the standard basis vectors for R 3 (that is, ej has a 1 in the jth position, and has 0 everywhere else). (a) Suppose that D is a 3 × 3 diagonal matrix. Show that e1, e2, e3 are eigenvectors of D. (b) Suppose that A is a 3 × 3 matrix, and that e1, e2, and e3 are eigenvectors of A. Is it true that A must be a diagonal...
in an inertial frame, two events E1 and E2 are separated by a distance 6 m...
in an inertial frame, two events E1 and E2 are separated by a distance 6 m in the x-direction. E1 occurs 4.0 s before event E2. An observer in inertial frame S' moving in the x-direction relative to frame S observes the events at the same location. what time interval does frane S' observe between the events?
What are the type of SN1, SN2, E1, and E2 mechanisms.
What are the type of SN1, SN2, E1, and E2 mechanisms.
Determine the resultant of the two waves E1 = 4.00 sin(100 πt) and E2 = 7.80...
Determine the resultant of the two waves E1 = 4.00 sin(100 πt) and E2 = 7.80 sin(100 πt + π/2). E1 + E2 =
Prove or give a counter example for "If E1 and E2 are independent, then they are...
Prove or give a counter example for "If E1 and E2 are independent, then they are conditionally independent given F."
What are the E1 and E2 products formed from 2-bromobutane?
What are the E1 and E2 products formed from 2-bromobutane?
Explain the basic differences in the E1 & E2 mechanism, in which alkyl halide react with...
Explain the basic differences in the E1 & E2 mechanism, in which alkyl halide react with bases to produce Alkenes?
Suppose that we have a sample space with five equally likely experimental outcomes: E1, E2, E3,...
Suppose that we have a sample space with five equally likely experimental outcomes: E1, E2, E3, E4, E5. let a = {E1, E2} B = {E3, E4} C = {E2, E3, E5} a. Find P(a), P(B), and P(C). b. Find P(a ∙ B). Are a and B mutually exclusive? c. Find ac, Cc, P(ac), and P(Cc). d. Finda∙Bc andP(a∙Bc). e. Find P(B ∙ C ).
?-ketogluterate dehydrogenase and pyruvate dehydrogenase catalyze similar reactions using the same reaction mechanisms. E1 and E2...
?-ketogluterate dehydrogenase and pyruvate dehydrogenase catalyze similar reactions using the same reaction mechanisms. E1 and E2 of the two enzyme complexes share a lot of similarities, however they are not identical. The E3 enzyme of the two enzyme complexes are identical. Keeping the functions of each of the three enzymes in mind, explain why it makes sense that the E1/E2 enzymes are only similar, whereas the E3 enzymes are identical.
ADVERTISEMENT
Need Online Homework Help?

Get Answers For Free
Most questions answered within 1 hours.

Ask a Question
ADVERTISEMENT