Question

Why is significant serum (in the blood stream) cholesterol reduction so difficult, and why

do most of the drugs designed to reduce cholesterol target the liver?

Answer 1

The reduction in serum cholesterol results decrease in LDL lipoprotein and its synthesis. This poses risk of heart disease (atherosclerotic cardiovascular) and diabetes. Serum cholesterol triglyceride concentration was associated with the risk of CHD. HMG-CoA reductase, a key enzyme in the synthesis of cholesterol. HMG-CoA reductase inhibitors (statins) used for lowering cholesterol levels. These inhibitors works by lowering LDL levels an an decrease in the levels of LDL. The pronounced adverse effects are muscle complications and high risk of diabetes. Statins are competitive inhibitors of HMG-CoA reductase, which leads to a decrease in cholesterol synthesis in the liver. statins reduce the production and secretion of VLDL particles by the liver.

Thank You So Much! Please Rate this answer as you wish.