Question

Why is significant serum (in the blood stream) cholesterol reduction so difficult, and why do most...

Why is significant serum (in the blood stream) cholesterol reduction so difficult, and why

do most of the drugs designed to reduce cholesterol target the liver?

Homework Answers

Answer #1

The reduction in serum cholesterol results decrease in LDL lipoprotein and its synthesis. This poses risk of heart disease (atherosclerotic cardiovascular) and diabetes. Serum cholesterol triglyceride concentration was associated with the risk of CHD. HMG-CoA reductase, a key enzyme in the synthesis of cholesterol. HMG-CoA reductase inhibitors (statins) used for lowering cholesterol levels. These inhibitors works by lowering LDL levels an an decrease in the levels of LDL. The pronounced adverse effects are muscle complications and high risk of diabetes. Statins are competitive inhibitors of HMG-CoA reductase, which leads to a decrease in cholesterol synthesis in the liver. statins reduce the production and secretion of VLDL particles by the liver.

Thank You So Much! Please Rate this answer as you wish.

Know the answer?
Your Answer:

Post as a guest

Your Name:

What's your source?

Earn Coins

Coins can be redeemed for fabulous gifts.

Not the answer you're looking for?
Ask your own homework help question
Similar Questions
Why is it so difficult to determine the appropriate price for an IPO? Who do you...
Why is it so difficult to determine the appropriate price for an IPO? Who do you think has the most input: the issuing firm, the underwriter, or investors? Explain 200 words.
Why do you think it is so difficult to find a cure for cancer?
Why do you think it is so difficult to find a cure for cancer?
What challenges seem the most difficult in leadership, and why? How do you envision yourself rising...
What challenges seem the most difficult in leadership, and why? How do you envision yourself rising to the demands of these types of challenges and/or crises?
1)Why do you think it is so difficult to find successful ERP implementation? 2. How do...
1)Why do you think it is so difficult to find successful ERP implementation? 2. How do you think cloud computing will help ERP implementations find success? 3. What advice would you give a company deciding to implement an ERP system? 4. How can integrating SCM, CRM, and ERP help improve business operations at your school?
1.   The disaccharide groups are: * 1 point A. Fructose, maltose, Galactose B. Lactose, fructose, glucose...
1.   The disaccharide groups are: * 1 point A. Fructose, maltose, Galactose B. Lactose, fructose, glucose C. Sucrose, glucose, Galactose D. Sucrose, lactose, maltose 2.   Which of the following are NOT used as fuel and are required in small quantities? * 1 point A. Essential nutrients B. Lipids C. Macronutrients D. Micronutrients 3.   Which of the following stores the greatest amount of energy in the body? * 1 point A. Vitamins B. Proteins C. Glycogen D. Minerals 4.   Proteins serve...
Why do you suppose the marketing of the tax shelters at KPMG grew so fast? a.Transformational...
Why do you suppose the marketing of the tax shelters at KPMG grew so fast? a.Transformational leadership b. Moral manager c. Social learning theory d. Moral intensity [The following information applies to the question.] In Chapter 4 we discussed the artificial tax shelter arrangements developed by KPMG LLP for wealthy clients that led to the settlement of a legal action with the Department of Treasury and the Internal Revenue Service. On August 29, 2005, KPMG admitted to criminal wrongdoing and...
READ THE CASE STUDY AND ANSWER THE FOLLOWING QUESTIONS 2nd CASE: An Unexplained Death A 65-year-old...
READ THE CASE STUDY AND ANSWER THE FOLLOWING QUESTIONS 2nd CASE: An Unexplained Death A 65-year-old man of Scandinavian descent was rushed to the Emergency Room of your local hospital after a family member discovered him unconscious in his home. The woman who dialed “911” told the dispatcher that the man, her brother, was the local librarian of the past 10 years and had no spouse or children. She reported that they had spoken the day before, and he had...
1.    Observations are all of the following, as an assessment technique, except a.    completed in informal...
1.    Observations are all of the following, as an assessment technique, except a.    completed in informal and formal (e.g., laboratory) settings b.    useful in providing information that may not be obtained through other assessment techniques c.    difficult to complete under some circumstances d.    useless in providing information that is of clinical relevance 2.    The MMPI-2 is what? a.    an IQ test b.    a projective test c.    an objective test d.    a blood test                            ...
Amir-Ali Mohamed was born into a family whose most prosperous days were behind them in Nemeyistan....
Amir-Ali Mohamed was born into a family whose most prosperous days were behind them in Nemeyistan. His father was an opium addict who slowly squandered the family savings on opium and several failed business ventures. Mohamed’s’ mother came from money, but her inheritance was largely gone by the time he was a youth. After her death, the family’s financial circumstances became so bad that Mohamed was forced to leave school before graduating in order to find fulltime work to support...
Pandora is the Internet’s most successful subscription radio service. As of June 2013, it had over...
Pandora is the Internet’s most successful subscription radio service. As of June 2013, it had over 200 million registered users (140 million of which access the service via a mobile device) and over 70 million active listeners. Pandora now accounts for more than 70% of all Internet radio listening hours and a 7% share of total U.S. radio listening (both traditional and Internet). At Pandora, users select a genre of music based on a favorite musician, and a computer algorithm...
ADVERTISEMENT
Need Online Homework Help?

Get Answers For Free
Most questions answered within 1 hours.

Ask a Question
ADVERTISEMENT