Question

Part A

Based on the possibility of  2.7×1092 conformations, estimate the conformational entropy change on folding a mole of this protein into a native structure with only one conformation.

Express your answer using three significant figures.

Part B

If the protein folds entirely into α helix with H bonds as the only source of enthalpy of stabilization, and each mole of H bonds contributes −5 kJmol to the enthalpy, estimate ΔHfolding. . Note that the ends of helices contain fewer hydrogen bonds per residue than in the middle as shown to the left.

Express your answer using tree significant figures.

Answer 1