Question

A leucine zipper is located on what kind of protein. Draw or briefly describe the general structure and a function of the leucine zipper

Answer 1

Many proteins that bind to deoxyribonucleic acid (DNA) and regulate gene expression. A leucine zipper is located on DNA binding proteins, it binds two helices together by in which two parallel alpha helices are adjacent to each other with the leucine side chains projecting from each helix binding together as shown in below image. (Reproduced to better understand in a 3D effect)

These can bind to DNA as homo- or heterodimers and will have alpha-helical segments that are about 30 residues long with a leucine in every 7th position. These zippers promotes general protein modules for protein interactions. When the protein is bound to the promoter, transcription is stimulated and the gene is "expressed".

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