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Calculate the concentration of a noncompetative inhibitor (K1= 2.9x10-4M) needed to yield 90% inhibition of an...

Calculate the concentration of a noncompetative inhibitor (K1= 2.9x10-4M) needed to yield 90% inhibition of an enzyme-catalyzed reaction.

The answer is 2.6x10-3M, I need to know how to find this answer. Thank you!

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Answer #1

The concentration of a noncompetative inhibitor (K1= 2.9x10-4M) needed to yield 90% inhibition of an enzyme-catalyzed reaction and the remaining inhibition = 100-90 = 10%

percentage inhibition = (Concentration of a noncompetative inhibitor) / (Remaining inhibition (100-90)) / K1 ​(1- inhibitied activity)

Concentration of a noncompetative inhibitor = (90 /100) / (10/100) x 2.9 x 10-4 M = 2.6 *10-3 M

Therefore,the Concentration of a noncompetative inhibitor = 2.6 *10-3 M

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