Here are pairs of compounsd that can be hydrolyzed. In which pair is ΔG0' of hydrolysis most similar. (the comparison is within each pair) - and why?
A. ATP and GTP
B. phosphoenolpyruvate and 1,3-bisphosphoglycerate
C. glucose-1-phosphate and glucose-6-phosphate
D. ATP and glucose-6-phosphate
For ATP (adenosin triphosphate), ΔG0= 30.5 kJ/mol and for GTP (Guanosin triphosphate) it is 30.1 kJ/mol .
Hence the answer is (A)
Reason: If we look into the structure of ATP and GTP we can see that the base attached to ribose has, negligible effect on the stability of the third phosphate. There is no effect of change in nitrogenous base on the third phosphate as they are too far to directly influence each other's stability. We can clearly interpret from these diagrams is that there would be no effect on the energy released by hydrolysis of the third phosphate by the nitogenous base present. It will remain similar in both cases.
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