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the first step of alpha- ketoglutarate dehydrogenase reaction involves decarboxylation of the substrate and leaves a...

the first step of alpha- ketoglutarate dehydrogenase reaction involves decarboxylation of the substrate and leaves a covalent TPP intermediate. Write a reasonable mechanism for this reaction.

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Answer #1

Carbanion of TPP :

Mechanism of decarboxylation of pyruvate dehydrogenase:

Mechanism of decarboxylation of -ketoglutarate dehydrogenase:

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