Question

A new weight loss pill has been introduced in Gotham that does not inhibit lipase but inhibits the uptake of dietary triglycerides by chylomicrons. Which of the following would most likely be the most true?

a.	triglycerides would be transported to muscle and adipose tissue

b.	triglycerides could not be broken down in the intestine

c.	triglycerides would increase in concentration in the intestinal lumen

d.	triglycerides would increase in concentration in the mucosal cell

e.	triglycerides could not be reformed in the mucosal cells

Answer 1

Answer:   e. triglycerides could not be reformed in the mucosal cells

lower production of insulin removes the inhibition of triglyceride breakdown, leading to the mobilization of fat stores. This is the principle of the weight loss seen in fasting and diets with reduced free sugar. fat-digesting enzymes from the pancreas (lipases) can split them into smaller molecules for absorption (split fatty acids from glycerol backbones...) [then all the pieces cling in bile balls and go through mucous to waiting intestinal cells... glycerol/short chain fatty acids pass directly through cells to blood and go to liver un aided. monoglycerides and longer chain fatty acids go into intestinal cells, reform into triglycerides and with protein, form chylomicrons which are lipoproteins that transport them through lymph to blood to liver].

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