Question

What is the history of Ion Exchange Chromatography? What was the first paper it was mentioned in?

Answer 1

Ion exchange chromatography is a technique used to separate ions and polar molecules based on the charge on the resin. The history goes like it was first employed by H.S Thompson in 1845 for separation of Ammonia from a manure sample by passing it through garden soil. A very primitive ion exchange method.

In 1901 F.Harm, K. Halse and other used artificial zeolite and successfully removed potassium from sugary liquids. Ot was the first instance of an industrial ion exchanger.

In 1923 J.Whiehorn pioneered use of ion exchanger in column chromatography.

1959 F. helfferich and A. Sober paved the way for current theory of ion exchange chromatography

The first official paper about ion exchange resins by Adams and Holmes was published in 1935