Consider the following isomerization reactions of some simple sugars and values for their standard Gibbs free energy ΔG°:
glucose-1-phosphate ⟶ glucose-6-phosphate ΔG° = −7.28 kJ/mol
fructose-6-phosphate ⟶ glucose-6-phosphate ΔG° = −1.67 kJ/mol
3.1 Calculate ΔG° for the isomerization of
glucose-1-phosphate to fructose-6-phosphate. [ANSWER =
-5.61 kJ/mol]
3.2 Calculate the equilibrium constant K for the
isomerization of glucose-1-phosphate to fructose-6-phosphate at
298K. [ANSWER = 9.62 ]
3.3. Suppose you dissolve fructose-6-phosphate in
water to prepare a 0.1 M solution. What are the concentrations of
fructose-6-phosphate and glucose-1-phosphate at equilibrium?
I JUST NEED PART 3.3
fructose -6-phosphate ---> glucose -6-phosphate , dG == - 1.67 KJ/mol = -1670 J/mol
we have relation dGo = -RT ln Keq
- 1670 J/mol = - 8.314 J/molK x 298 K x ln Keq
Keq = exp ( 1670 /8.314 x 298) = 1.96
At equilibrium fructose-1-6-phosphate concentration = 0.1-X ,
Glucose-6-phosphate = X
we have Keq = [Glucose-6-phosphate] / [fructose-6-phosphate]
1.96 = ( X) / ( 0.1-X)
X = 0.066
hence at equilibrium glucose -6-phosphate concentration = 0.066 M
fructose -6-phopshate concentration = 0.1-0.066 = 0.034 M
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