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What is the net ATP yield for glucose that is converted first to 2,3 BPG before...

What is the net ATP yield for glucose that is converted first to 2,3 BPG before re-entering glycolysis? Explain.

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Answer #1

Stage 1 is the investment stage. 2 mols of ATP are consumed for each mol of glucose.

Stage 2 fructose-1,6-bisphosphate is cleaved into two 3-carbon units of glycerladehyde-3-phosphate.

Stage 3 is the harvesting stage. 4 mols of ATP and 2 mols of NADH are gained from two mol glycerladehyde-3-phosphate. This ATP is a result of substrate-level phosphorylation.

Total: -2 ATP + 2 NADH + 4 ATP = 2 ATP + 2 NADH

each NADH yields 2.5 ATP, so final ATPs are

net ATP yield = 2 ATP + (2 x 2.5) = 7 ATP

net ATP yield = 7 ATP ( before re-entering glycolysis)

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