Question

pKa = 7.4

	Stomach (pH = 2)	Small Intestine (pH = 6)	Blodd (pH = 7.4)
Non- ionized (%)	?	?	?
Ionized %)	?	?	?

Please fill in the table,

and show me the work

Answer 1

Using the hessley henderbach equation

pH = pKa + log[ionizedform/non-ionizedform]

a) Stomach (pH=2)

2 = 7.4 + log[ionizedform/non-ionizedform]

-5.4 = log[ionizedform/non-ionizedform]

ionizedform/non-ionizedform = 10^(-5.4) = 3.981 * 10^(-6)

Percentage in non-ionized form = 99.99996%

Percentage in ionized form = 3.98 * 10^(-4)%

b) Small intestine(pH=6)

6 = 7.4 + log[ionizedform/non-ionizedform]

-1.4 = log[ionizedform/non-ionizedform]

ionizedform/non-ionizedform = 10^(-1.4) = 0.0398

Percentage in non-ionized form = 96.17%

Percentage in ionized form = 3.83%

c) Blood(pH=7.4)

7.4 = 7.4 + log[ionizedform/non-ionizedform]

0 = log[ionizedform/non-ionizedform]

ionizedform/non-ionizedform = 1

Percentage in non-ionized form = 50%

Percentage in ionized form = 50%