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Describe how the desensitization of a receptor differs with acute exposure compared to chronic exposure regarding...

Describe how the desensitization of a receptor differs with acute exposure compared to chronic exposure regarding the number/location of receptors present and reversibility of the desensitization (no more than 8 sentences)

(Pharmacology - Topic: Receptor Regulation, Tolerance and Dependence)

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Desensitization of receptor means when receptor decrease and stop the response to agonist binding.

When agonist bonds with the receptor for a long time by repeated dosing. The receptor decreases the intrinsic activity of an agonist it is called chronic desensitization.

Where acute desensitization leads due to a single high dose. A single high dose of agonist also leads desensitization.

These all process follow the mechanism of tachyphylaxis and tolerance.

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