Question

An ophthalmic solution contains tafluprost, 0.0015% w/v, available in 0.3 mL pouches for single use. Calculate

(a) the quantity of tafluprost, in micrograms, in each pouch

b) the number of single-dose pouches that the manufacturer may prepare from each 1 g of drug.

Answer 1

a) %w/v means, the amount of substance present in 100 ml solution.

so that, 0.0015 g tafluprost present in 100 ml solution.

the quantity of tafluprost in each pouch = 0.0015*0.3/100 = 4.5*10^-6 g

b)    single-dose pouches containing drug = 4.5*10^-6 g

  
total number ofsingle-dose pouch can be prepared = 1/(4.5*10^-6)

          = 222222
     
          = 2.22*10^5